"In a move that has stunned Washington, D.C., longtime Pennsylvania Republican Senator Arlen Specter has switched parties. He is the first Republican senator to switch teams since Senator Larry Craig, I guess." --Jay Leno
"Republican Senator Arlen Specter has contracted donkey flu. Folks, this disease is now officially out of control. Back in 2004, we thought we had it contained to the coasts and the cities, but then it mutated and tore through the country [on screen: a map of 2004, showing most states as red states. The next map, from 2008, showed more blue states than there previously were]. Republicans tried to fight it off, but their white cells weren't strong enough, although they were very, very white [on screen: photos of four prominent Republicans]. Now, we should have seen this coming, folks. Specter was exhibiting the classic symptoms of donkey flu: mild fever, and being 21 points behind in Republican primary polls. I want to warn Maine Republican Senators Olympia Snowe and Susan Collins to take every possible precaution. Donkey flu is highly contagious and virtually incurable. Only one man has ever beaten it, but clearly, it took a horrible toll [on screen: a photo of Independent Senator Joseph Lieberman of Connecticut]." --Stephen Colbert
"This really is big, because Specter's move puts the Democrats within a hair's breath of a unfilibusterable 60-seat Senate majority. So now it appears the Senate's balance of power, in many respects, the future of our nation is in the hands of Al Franken. What a country!" --Jon Stewart
"Specter announced he'd become a Democrat and the Republicans are like, 'Yeah, he's been a Democrat for about 15 years.'" --Craig Ferguson
"By the way, this marks 100 days for President Obama in office as the leader of the free world. Meanwhile, to give you an idea what else is going on, today, John McCain was waxing his Pontiac." --David Letterman
"President Obama, if you take a look at it, has accomplished quite a lot in his first 100 days. By way of comparison, take a look at George W. Bush's first 100 days in office. This is in his memoir. So, according to that, Bush spent 100 days in the Oval Office looking for the corner." --David Letterman
"In a new interview, Iranian President Mahmoud Ahmadinejad complained that President Obama hasn't been returning his messages. No offense Mahmoud, but maybe he's just not that into you." --Craig Ferguson
"Yesterday was 'Take Your Kid to Work Day.' It used to be 'Take Your Daughter to Work Day,' but political correctness took over. Thanks to the economy, there’s a new special day for parents and kids – 'Take Your Child to Where You Used to Work Day.' This day shows that daddy and mommy didn’t always just sit around in their underwear." --Jimmy Kimmel
"As you know, a big holiday is coming next week here in Los Angeles and Mexico: Sicko de Mayo." --Jay Leno
"See all those people on the news walking around wearing those surgical masks, huh? For the swine flu. Suddenly Michael Jackson is not so crazy, huh? Yeah! I think we owe Michael an apology." --Jay Leno
"Remember the good old days when we thought the only bad pork was in the Federal budget?" --Jay Leno
"Give you an idea how bad it is with the swine flu, earlier today, the U.S. took down the wall between the United States and Mexico and replaced it with a giant sneeze guard." --Jay Leno
"They say this outbreak of swine flu got its start in Mexico and then came up here. You know what Wal-Mart calls something that got its start in Mexico and came up here? Employees." --Jay Leno
"Well, another pilot has been taken off a plane for being drunk. This time it was an Air Canada pilot who was about to fly from London to Calgary. They took him off the plane before he could do something really stupid, you know, like fly low over Manhattan." --Jay Leno
"Did you see that, the 747 jet flying low over New York City? It caused a huge panic. Some government idiot thought it would be a good idea to buzz the city to get pictures of planes flying over the Statue of Liberty. But they didn't warn anybody. What's the government's next big idea? 'Hey, let's send a guy in a pirate costume to Captain Richard Phillips' house.'" --Jay Leno
"And I love this. At the Summit of the Americas, the leaders of Cuba, Nicaragua, and Venezuela all agreed that capitalism will destroy the planet. Then they all hopped in their private jets and returned to their huge palaces." --Jay Leno
"Well, the U.S. government is saying look out for the swine flu, which apparently comes from Mexico. Thank God we have an airtight border with that country. So, the U.S. is going to be fine." --David Letterman
"Here's something else I didn't want to bring up but I have to. You folks in the balcony, be careful. You may be buzzed by Air Force One. So look out." --David Letterman
"This is, I mean, this is exciting. Air Force One was in New York City and apparently nobody knew. They didn't make the call. Hello! Air Force One comes to New York City and wants to take some pictures. They send it right up and start buzzing New York City. I mean, isn't this something you would expect from the Bush Administration?" --David Letterman
"Great to be back. As you know, I was sick for two days last week. Had to go to the hospital after I ate a raw pig a friend brought back from Mexico." --Jay Leno
"But you learn a lot about the system. You know, like, people say, 'Oh, where do hospitals get the nerve to charge $10 for an aspirin?' See, this is why President Obama wants to do something about healthcare in this country. See, under his plan, hospital aspirin only costs a dollar maximum. Of course, there would be a $9 tax on it." --Jay Leno
"I wasn't that sick, but some people are, because of this swine flu, which has knocked the torture stuff right off the front page. You notice that? So, it's obvious who is spreading the swine flu. Dick Cheney." --Jay Leno
"Well, it's interesting. They call it swine flu because they think it originated either with pigs or an AIG executive." --Jay Leno
"Next month in Canada, former President George W. Bush and former President Bill Clinton will have a debate. They're gonna debate each other. The topic will be, 'which is better, getting in bed with big oil or big women?" --Jay Leno
"Yes, Obama is marking 100 days as the leader of the free world. Meanwhile, John McCain was putting his Glenn Miller records in storage today." --David Letterman
"I think this is a first for President Obama. This weekend he played golf. President Obama apparently, and at one point, and this happens, you know, you play golf, he got stuck really deep in a sand trap. Same thing happened to George Bush, and it's called Iraq." --David Letterman
"I was surprised. Obama is a pretty good golfer. And he missed a couple of putts, or he would have broken 90. Could have broken 90. Missed a couple of putts. Speaking of a couple of putz, anybody hear anything of Bush and Cheney?" --David Letterman
"In economic news, ExxonMobil's profit last year was $45 billion. In second place was the company that makes those foreclosure signs." --David Letterman
[gathered from NYTimes Laughlines]